Cyclooxygenase (COX) is a key step in the conversion of arachidonic acid to PGH2. Specifically, PGH2 is a direct substrate…
Interleukin-1 receptor-associated kinase 4 (IRAK4) is a key node in innate inflammatory signaling. It is also directly downstream of the…
mPGES-1 is the terminal enzyme one-step downstream of COX2. It also is the unstable peroxide intermediate from arachidonate catabolism. mPGES-1…
NF-κB-mediated inflammation is a major pathology in kidney diseases, such as non-kidney inflammatory diseases, and rheumatoid arthritis. HIV infection in…
Infiltration of leukocytes from the peripheral circulation into tissues such as the gut mucosa is an important aspect of immune…