![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/09/PF06650833-is-an-Orally-Active-IRAK4-Inhibitor-2020-09-15.jpg)
Interleukin-1 receptor-associated kinase 4 (IRAK4) is a key node in innate inflammatory signaling. It is also directly downstream of the…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/08/PF-9184-is-a-Highly-Selective-of-Human-Microsomal-PGES-1-Inhibitor-2020-08-04.jpg)
mPGES-1 is the terminal enzyme one-step downstream of COX2. It also is the unstable peroxide intermediate from arachidonate catabolism. mPGES-1…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/01/MS417-is-a-BET-Specific-BRD4-Inhibitor-2020-01-17.jpg)
NF-κB-mediated inflammation is a major pathology in kidney diseases, such as non-kidney inflammatory diseases, and rheumatoid arthritis. HIV infection in…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/09/E6130-is-an-Orally-Active-and-Highly-Selective-CX3CR1-Modulator-2019-09-07.jpg)
Infiltration of leukocytes from the peripheral circulation into tissues such as the gut mucosa is an important aspect of immune…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/08/SR2211-is-a-Selective-RORγ-Inverse-Agonist-2019-08-29.jpg)
Retinoic acid receptor-related orphan receptors (RORs) are ligand-dependent transcriptional factors and members of the nuclear receptor superfamily. In fact, RORs…