GABA (γ-aminobutyric acid-gated) is the chief inhibitory neurotransmitter in the developmentally mature mammalian central nervous system. Besides, Its principal role is reducing neuronal excitability throughout the nervous system. GABACl (γ-aminobutyric…
Malaria is one of the most widespread and ancient infectious diseases of humanity. In particular, Dihydroorotate dehydrogenase (DHODH) acts as a target for the development of new antimalarials. In addition,…
Dirofilaria repens is a filarial parasite of canids transmitting by mosquitoes. Besides, adult worms mainly exist in the subcutaneous tissue of dogs. And it deposits microfilariae that circulate in the…
Malaria is a mosquito-borne infectious disease that affects humans and other animals. Specifically, malaria caused Symptoms usually including fever, fatigue, vomiting and headache. Besides, malaria is due to the single-celled…
Cleavage and polyadenylation specificity factor (CPSF) is relevant to the cleavage of the 3' signaling region from a newly synthesized pre-messenger RNA (pre-mRNA) molecule. Specifically, it is in the process…
The apicomplexan parasite Cryptosporidium is one of the leading causes of infectious diarrhea in children. Cryptosporidiosis is also a well-recognized opportunistic infection in adult AIDS and transplant patients. The Cryptosporidium…
PfCLK3 is a protein kinase essential for maintaining the asexual blood stage of both P. falciparum and P. berghei. In mammalian cells, the CLK protein kinase family and the closely related SRPK family…
As previously introduced, we all have known that RRx-001, a hypoxia-selective epigenetic agent and a radio- and chem-sensitizer. Additionally, it triggers apoptosis and overcomes drug resistance in myeloma. RRx-001 exhibits…
Nowadays, cryptosporidiosis is no stranger to us. We have mentioned such disease in our previous blogs. It is a main cause of diarrhea in children under 2 years old especially…
Cryptosporidiosis is a kind of parasitic diseases, caused by Cryptosporidium. The parasite commonly exists in HIV-positive patients. It is harmful to the distal small intestine and affects the respiratory tract…