Abelacimab (MAA868) is a Fully Human IgG1 mAb That Binds to Factor XI
Factor XI (FXI) is a serine protease that in humans is encoded by the F11 gene. FXI mainly exists in the liver and is present in the circulation as an…
BMS-986120, an Orally Active PAR4 Inhibitor, Inhibits Arterial Thrombosis
Platelets are central to thrombus formation, the leading cause of global mortality. PAR4 (protease-activated receptor 4) is a G-protein coupled receptor. Meanwhile, PAR4 together with PAR1 is responsible for thrombin-mediated…