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Immune System Research

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Metabolic Disease obesity Type 2 Diabetes Mellitus

Semaglutide is a GLP-1 Receptor Agonist for Type 2 Diabetes Research

Edward Jenner 2023-04-28

The GLP receptors belong to a family comprising two members: the GLP-1 receptor (GLP1R, or GLP-1R) and the GLP-2 receptor (GLP2R, or GLP-1R), which can be activated by glucagon-like peptides…

Antibodydrug Diabetic Complication obesity Type 2 Diabetes Mellitus

Crotedumab (REGN1193) is an Anti-GCGR IgG4 Monoclonal Antibody

Edward Jenner 2023-01-10

Glucagon plays an important role in glucose metabolism. Upon hypoglycemia, pancreatic alpha cells can secrete glucagon which stimulates hepatic glucose production. However increased glucagon concentrations contribute to diabetic hyperglycemia. In…

Metabolic Disease obesity Type 2 Diabetes Mellitus

LY3437943 is a Triple Agonist of GCGR/GIPR/GLP-1R

Edward Jenner 2022-11-10

Glucagon receptor (GCGR), a 62 kDa protein, is a member of the class B G-protein coupled family of receptors. GCGR mainly exists in the liver and in the kidney. In…

Metabolic Disease obesity Type 2 Diabetes Mellitus

Cotadutide is a Potent GLP-1 and GCGR Dual Agonist

Edward Jenner 2022-11-05

Glucagon-like peptide-1 (GLP-1) is a 30- or 31-amino acid peptide hormone produced and secreted by intestinal enteroendocrine L-cells and certain neurons within the nucleus of the solitary tract in the brainstem upon food consumption. GLP-1 can…

Metabolic Disease Metabolic Disorder Type 2 Diabetes Mellitus

PF-06649298 is an Orally Active SLC13A5 (NaCT) Inhibitor, Regulating Glucose and Lipid Metabolism

Edward Jenner 2022-10-09

The SLC13 family comprises five family members. co-transports, NaS1 and NaS2. Sodium-coupled citrate transporter (NaCT) and NaDC1 and NaDC3 are responsible for transporting cellular anionic intermediates. For example, citrate can…

Autoimmune Encephalomyelitis Inflammation Metabolic Disease Multiple Sclerosis Type 2 Diabetes Mellitus

MASM7 is a Mitofusin Activator and Can Achieve Mitochondrial Fusion

Edward Jenner 2022-09-01

Mitochondria fusion and division can produce the majority of energy to sustain cellular activity. Mitochondria is a highly dynamic organelle. It can undergo the physiological process of fusion and fission.…

Metabolic Disease Type 2 Diabetes Mellitus

PBI-6DNJ is an Orally Active Multivalent Glycosidase Inhibitor

Edward Jenner 2022-08-13

Glycosidases are enzymes catalyzing the hydrolysis of glycosidic bonds in complex sugars. They take part in the biosynthesis of the oligosaccharide chains and quality control mechanisms in the endoplasmic reticulum…

Metabolic Disease Type 2 Diabetes Mellitus

Dorzagliatin (HMS5552), is a Dual-Acting Glucokinase (GK) Activator

Edward Jenner 2022-06-09

Glucokinase (GK), also known as hexokinase IV or D, is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. While, Glucokinase occurs in cells in the liver, pancreas, gut, and…

Metabolic Disease Type 2 Diabetes Mellitus

Anagliptin is a Highly Selective, Potent Inhibitor of Dipeptidyl Peptidase 4 (DPP-4)

Edward Jenner 2022-05-12

Dipeptidyl Peptidases are widely distributed exopeptidases that possess central role in proteolysis. The dipeptidyl peptidase family, including DPP-4 DPP-7, DPP-8, DPP-9, and fibroblast activation protein. Among them, DPP-4 (CD26) is…

Metabolic Disorder Type 2 Diabetes Mellitus

Licogliflozin is a dual SGLT1 and SGLT2 Inhibitor

Edward Jenner 2022-01-18

In general, obesity more greatly contributes to the global burden of disease (also associated with co-morbidities) in recent years . For instance, there are type 2 diabetes mellitus (T2DM), hypertension,…

Recent Posts

  • PRX-08066 is an orally active 5-HT2BR Antagonist with Vasodilation Effect for PAH
  • Apocynin is a NADPH oxidase (NOX) Inhibitor for Metabolic and Inflammation Research
  • Xylometazoline is an α-adrenergic Receptor Agonist for Nose Stuffiness Research
  • Elafibranor is a PPARα/δ Agonist for Metabolic Disease Research
  • Doravirine is a HIV-1 Inhibitor for Infection Research

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You Missed

Pulmonary Arterial Hypertension (PAH)

PRX-08066 is an orally active 5-HT2BR Antagonist with Vasodilation Effect for PAH

Cancer Immune Metabolic Disease

Apocynin is a NADPH oxidase (NOX) Inhibitor for Metabolic and Inflammation Research

Uncategorized

Xylometazoline is an α-adrenergic Receptor Agonist for Nose Stuffiness Research

NASH obesity

Elafibranor is a PPARα/δ Agonist for Metabolic Disease Research

Immune System Research

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