Receptor-interacting protein (RIP) kinases are a group of threonine/serine protein kinases. There are seven members of the RIPK family, RIPK1-7. RIP kinases are cellular signaling molecules that are critical for…
Sirtuin (Sir2 proteins) is a class of proteins. And it possesses either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in…
Tyrosine kinase 2 (TYK2) is a member of the JAK kinase family. Besides, it regulates signal transduction downstream of the IL-23/IL-12 pathway and the type I interferon family receptor, pairing…
CD40 is a transmembrane glycoprotein. CD40 can express on B cells and antigen presenting cells (APCs) such as monocytes, macrophages, and dendritic cells (DC). It also expresses on platelets. Furthermore, …