ARD-266 is a Highly Potent AR PROTAC Degrader
In our cancer blog, we have introduced a large number of PROTACs. A1874 exhibits a nultin-based BRD4-degrading PROTAC. MT-802 shows as a PROTAC degrader of BTK for C481S mutant CLL…
In our cancer blog, we have introduced a large number of PROTACs. A1874 exhibits a nultin-based BRD4-degrading PROTAC. MT-802 shows as a PROTAC degrader of BTK for C481S mutant CLL…
Glutamate-oxaloacetate transaminase (GOT) is a Pyr aldehyde phosphate-dependent enzyme. Specifically, it exists in the form of cytoplasm and mitochondria, GOT1, and GOT2, respectively. Besides, GOT plays a role in amino…
Members of the activating protein 1 (AP-1) and nuclear factor-κB (NF-κB) families of transcription factors plays an important role in many essential physiological and pathological processes. These transcription factors are…
Liver fibrosis is the accumulation of connective tissue in the liver. The consequence results from an imbalance between production and degradation of the extracellular matrix. Because inflammation histologically presents in…
AMP-activated protein kinase (AMPK) is a central regulator of cellular and whole-body energy homeostasis. AMPK regulates cellular energy levels by balancing nutrient availability and energy demand via its control of…
Interleukin 10 (IL-10) is an anti-inflammatory cytokine. Specifically, IL-10 is a cytokine with multiple effects in immune regulation and inflammation. Besides, it downregulated Th1 cytokines, class II MHC antigens, and…
Inhalation and deposition of Aspergillus conidia in the lung is the most common route of infection for patients. Existing antifungal medicines are predominantly in orally or systemically. These frequently exploited routes…
Hsp90 is a molecular chaperone, it is essential for the conformational stability and activity of many key oncogenic proteins. These proteins include not only kinases such as ErbB2, B-Raf, Alk,…
Integrin α4β1 (VLA-4) promotes the immune system's inflammatory response by helping white blood cells move to tissues that need inflammation. Specifically, VLA-4 is a key factor in cell adhesion. Besides,…
In previous blogs, we have introduced a lot of PROTAC based degraders, including TD-428, HJB97, A1874, etc. Coincidentally most of them are all PROTAC-based BET degraders. Today, I’d like to…