![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/09/Tofacitinib-is-an-Orally-Active-JAK-Inhibitor-2021-09-24.jpg)
The Janus kinase (JAK) family of protein-tyrosine kinase has four members: JAK1, JAK2, JAK3, and TYK2. The Janus kinases share…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/11/GNF362-is-a-Highly-Selective-and-Orally-Active-Itpkb-Inhibitor-2019-12-3.jpg)
In mature lymphocytes, the Spatio-temporal regulation of Ca2+ modulates signaling pathways. They serve to control a variety of cellular responses, such…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/12/PF-06651600-is-a-Orally-Active-and-Covalent-JAK3-Selective-Inhibitor-2019-12-2.jpg)
JAK/STAT-dependent cytokines are essential for the development, proliferation, and function of T-cells. The JAK family of nonreceptor tyrosine kinases is…