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Category: Antigen-Induced Arthritis

GNF362 is a Highly Selective and Orally Active Itpkb Inhibitor

2019-12-03 Edward Jenner

In mature lymphocytes, the Spatio-temporal regulation of Ca2+ modulates signaling pathways. They serve to control a variety of cellular responses, such…

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Posted in: Antigen-Induced Arthritis, Autoimmune Disorders, Immunotherapy Filed under: Itpkb, T Cell

PF-06651600 is a Orally Active and Covalent JAK3-Selective Inhibitor

2019-12-02 Edward Jenner

JAK/STAT-dependent cytokines are essential for the development, proliferation, and function of T-cells. The JAK family of nonreceptor tyrosine kinases is…

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Posted in: Antigen-Induced Arthritis, Arthritis, Immunotherapy Filed under: Interleukin, JAK, Th1, Th17
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