PI3Kδ is a lipid kinase mainly expressed in hematopoietic cells and responsible for key signal transduction in cells of the immune system. Antigens can acutely activate PI3Kδ in B and…
The Janus kinase (JAK) family of protein-tyrosine kinase has four members: JAK1, JAK2, JAK3, and TYK2. The Janus kinases share seven distinct JAK homology (JH1-JH7) domains. These proteins possess an…
In mature lymphocytes, the Spatio-temporal regulation of Ca2+ modulates signaling pathways. They serve to control a variety of cellular responses, such as activation, differentiation, effector function, and cell death. Thus, targeting…
JAK/STAT-dependent cytokines are essential for the development, proliferation, and function of T-cells. The JAK family of nonreceptor tyrosine kinases is composed of four isoforms: JAK1, JAK2, JAK3, and TYK2. Functioning…