Inflammation involving the innate and adaptive immune systems is a normal response to infection. However, when allowed to continue unchecked, inflammation may result in autoimmune or autoinflammatory disorders, neurodegenerative disease,…
JNJ-61803534 is a potent and orally active RORγt inverse agonist. JNJ-61803534 exhibits anti-inflammatory activity. It inhibits IL-17A production in human CD4+ T cells under Th17 differentiation conditions. JNJ-61803534 (1 nM-1…
Interleukin-2 (IL-2) is a cytokine from activated T cells. IL-2 plays a critical function in the generation, differentiation, survival, and homeostasis of immune effector cells. Moreover, IL-2 functions to expand…