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Category: Asthma

GS143 is a Selec­tive IκBα Ubiquitination Inhibitor

2020-09-01 Edward Jenner

GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. Firstly, when GS143…

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Posted in: Asthma, Bronchial Airway Infection, Cancer Immunology, Inflammation Filed under: IκB, NF-κB, p53, Th2, Ubiquitination, β-catenin

PF-610355 is a Long-Acting Inhaled β2-Adrenoreceptor Agonist

2020-05-23 Edward Jenner

β2-adrenoreceptor is a kind of β-adrenergic receptor across the cell membrane, which binds to adrenaline. Specifically, Adrenaline is a kind…

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Posted in: Asthma, Chronic Obstructive Pulmonary Disease Filed under: Adrenoreceptor, COPD, Long-Acting

CAY10471 is a Selective and Orally Active CRTH2 Antagonist

2020-05-07 Edward Jenner

CAY10471 (TM30089) is a potent, selective, and orally active prostaglandin D2 receptor CRTH2 antagonist. In PC12 cells, CAY10471 blocks 15d-PGJ2-induced…

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Posted in: Allergy, Asthma, Fibrosis, Kidney Fibrosis, Rhinitis Filed under: CHS, CRTH2, Prostaglandin

Valategrast is an Orally Active Integrin α4β1 and α4β7 Antagonist

2020-04-08 Edward Jenner

Asthma is an inflammatory disorder of the airways. Moreover, asthma is a long-term disease of the lungs. The features of…

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Posted in: Asthma Filed under: COPD, Integrin, VAL-4, α4β1, α4β7

AZD9898 is an Orally Active LTC4S Inhibitor for Asthma Treatment

2019-10-02 Edward Jenner

The arachidonic acid cascade forms a plethora of proinflammatory and pro-resolution lipid metabolites, including prostaglandins, thromboxanes, and leukotrienes. In particular,…

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Posted in: Asthma, Bronchial Airway Infection Filed under: Anti-Inflammatory, LTC4S

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