Parkinson’s disease (PD) is the second common progressive neurodegenerative disorder next to Alzheimer’s disease. The pathological hallmark of Parkinson’s disease includes progressive loss of dopaminergic cells present in the substantia…
Dopamine D1 receptor is a G protein-coupled receptor that is one of the dopamine receptors. It exhibits cognitive functions such as memory and attention controlled by dopamine. Specifically, it regulates…
Dopamine Receptors belong the family of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). There are at least five subtypes of dopamine receptors, D1, D2,…
Autophagy is a conserved degradation pathway. Autophagy maintains cellular homeostasis in the cell by directing the clearance of old and abnormal proteins or organelles. However, autophagy dysregulates leads to many…
5-HT1A receptor is a subtype of 5-HT receptors that bind 5-HT. It is a G protein-coupled receptor that can couple to Gi proteins. In the brain, 5-HT1A activation mediates hyperpolarization…