Hematopoietic stem and progenitor cells (HSPCs) reside is in a specialized microenvironment. It also refers to the stem cell niche, which regulates critical HSPC processes, such as self-renewal and differentiation….
The BET (bromodomain and extraterminal domain) family includes BRDT, BRD2, BRD3, and BRD4 epigenetic reader proteins. They contain N-terminal tandem bromodomains, a structural feature that enables the recognition and binding…
Interleukin-2 (IL-2) is a pleiotropic cytokine and controls the differentiation and homeostasis of both pro- and anti-inflammatory T cells. The IL-2 receptor couples to JAK tyrosine kinases and activates the…
Sphingosine-1-phosphate (S1P) is a ligand for G-protein-coupled receptors, it is responsible for some cell-intrinsic and extrinsic activities. RPC1063 is a potent and selective S1PR1 modulator. It emerges as a new…
Receptor Interacting Kinase 2 (RIPK2) is an adaptor kinase that targeting for the treatment of various inflammatory diseases. In addition, RIPK2 is a potential drug target, particularly in inflammatory bowel…