Abl1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase. Specifically, it is relevant to cell differentiation, cell division, cell adhesion, and stress response. Deletion of SH3 domain makes Abl1…
5-Lipoxygenase-activating protein (FLAP) is essential for cellular leukotriene synthesis. FLAP is the target of leukotriene biosynthesis inhibitors. The 5-lipoxygenase pathway is responsible for the production of leukotrienes, lipid mediators derived…
Chronic kidney disease (CKD) affects approximately 10% of the adult population in developed countries. Renal fibrosis plays a pivotal role in the development and progression of CKD as well as…
Type II topoisomerases (TOP2s) can alter DNA topology. And it plays an important role in replication, transcription, recombination, and chromosome condensation and segregation. Passage of a second DNA segment through…
5-HT receptors are a group of G protein-coupled receptors and ligand-gated ion channels in the central nervous system and peripheral nervous system. They mediate excitatory and inhibitory neurotransmission. Specifically, Serotonin…
Cardiac myosin is the major target of the autoimmune response in many cases of myocarditis in humans and mice. Omecamtiv mecarbil is a first-in-class cardiac myosin activator. Omecamtiv mecarbil is…
The clinical use of tetracycline has a long history, dating back to 1948. And Tetracycline antibiotics are sought after because they are "broad-spectrum antibiotics" that are effective against a variety…
Transient receptor potential (TRP) channels are large and nonselective cation channels. It can respond to a wide range of chemical and physical stimuli and biophysical properties. TRPM3 acts as a…
The melatonin receptor is a G protein-coupled receptor (GPCR) that binds to melatonin. Specifically, receptors are crucial in the signal cascade of melatonin. In the field of chronobiology, melatonin is the…