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Tapinarof is a Natural Aryl Hydrocarbon Receptor (AhR) Agonist
Tapinarof (GSK2894512) is a naturally-derived small molecule produced by bacterial symbionts of entomopathogenic nematodes. Especially, Tapinarof displays significant efficacy in psoriasis and atopic dermatitis (AD) modls. Psoriasis vulgaris is a…
Rolipram is a Selective Phosphodiesterases PDE4 Inhibitor
Phosphodiesterases (PDEs) are enzymes that convert cyclic nucleotides (cAMP and cGMP) to their corresponding 5′-AMP and 5′-GMP in order to inactivate the cyclic nucleotides. There are currently 11 members in…
Purmorphamine is a Smoothened/Smo Receptor Agonist
Smoothened (Smo), a class Frizzled G protein-coupled receptor (class F GPCR), transduces the Hedgehog (Hh) signal across the cell membrane. The canonical Hh pathway functions through major Hh molecules such…
Oteseconazole is an Orally Active Anti-Fungal Agent
Fungal infections are a common occurrence, with an estimated worldwide prevalence of 20% to 25%. Consistent with most of Europe and the United States, a recent retrospective study found that…
Calyculin A is a PP1 and PP2A Inhibitor
A protein phosphatase is a phosphatase enzyme that removes a phosphate group from the phosphorylated amino acid residue of its substrate protein. Protein phosphatases (PPs) are the primary effectors of…
GYY4137 is a Slow Releasing H2S Donor with Vasodilator and Antihypertensive Activity
Hydrogen sulfide (H2S), a recognized environmental pollutant, comes from a wide range of sources. For example, H2S will be produced in the process of plant protein corruption, the decomposition of…
Tideglusib is an Irreversible GSK-3 Inhibitor
Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase. Specifically, the enzyme is a key regulator of many signaling pathways. It includes cellular responses to Wnt, receptor tyrosine kinase,…
Avibactam is a Covalent and Reversible non-β-Lactamase Inhibitor
Some Gram-negative pathogens have accumulated enough resistance mechanisms to render them virtually untreatable by modern antibacterial chemotherapy. A mainstay for the treatment of Gram-negative infections is the β-lactam classes of…
Tipifarnib Binds to and Inhibits Farnesyltransferase (FTase)
Farnesyl Transferase (FTase) is a heterodimeric enzyme containing α and β subunit in mammalian cells. FTase is one of the three enzymes in the prenyltransferase group. The activity of FTase…