Glioblastoma (GBM) is the most common and most aggressive primary malignant brain tumour in adults, with a high morbidity, high mortality and poor patient prognosis. Platinum-based drugs, including cisplatin, are…
Phosphoinositide 3-kinases (PI3Ks) are a family of enzymes that catalyze the phosphorylation of the 3-hydroxyl position of the inositol ring. A wide variety of different stimuli activate PI3Ks. The stimuli…
PI3Kδ belongs to the class I Phosphoinositide 3-kinases (PI3Ks). PI3Kδ plays a critical role in chronic obstructive pulmonary disease (COPD). IHMT-PI3Kδ-372 is a potent and selective PI3Kδ inhibitor for the…