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Immune System Research

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Immune System Research

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PRE-084 is a S1R Agonist for Cardiovascular and Neurological Disease Research

Edward Jenner 2023-05-24

The sigma-1 receptor (σ1R, S1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor. Moreover, the…

Alzheimer's disease

MR2938 Is A Dual AChE And BChE Inhibitor for Alzheimer’s Disease Research

Edward Jenner 2023-05-19

AChE and BChE are hydrolases of the neurotransmitter acetylcholine (ACh). Alzheimer's disease is a devastating neurodegenerative disease characterized by memory and cognitive decline. Specifically, Its pathological pathway also involves the deposition…

Alzheimer's disease

SD-6 is an Orally Active hAChE/hBChE Inhibitor for Alzheimer’s Disease Research

Edward Jenner 2023-05-12

Alzheimer's disease (AD) is the most common form of dementia. The cholinesterase enzymes (ChEs), i.e., AChE and butyrylcholine esterase (BChE) inhibitors, are the most promising therapeutic strategy. Firstly, it can…

Alzheimer's disease Neurological Disease

Yonkenafil (Tunodafil) is a PDE5 Inhibitor for Alzheimer’s Disease Research

Edward Jenner 2023-05-08

Phosphodiesterases (PDEs) are a class of enzymes that hydrolyze cyclic phosphodiester bonds, breaking them down into monophosphates and nucleotides. This enzyme widely exists in organisms and participates in the regulation…

Alzheimer Alzheimer's disease Neurological Disease Parkinson’s Schizophrenia

TC-2153 is STEP Inhibitor with Psychotropic Activity and Low Acute Toxicity

Edward Jenner 2023-04-21

Striatal-enriched protein tyrosine phosphatase (STEP) is a CNS-rich protein associated with a variety of neurological and neuropsychiatric disorders. Firstly, it is expressed exclusively in the central nervous system. Then, it…

Alzheimer Parkinson’s

DN-1289 is an Orally Active and Selective Inhibitor of DLK and LZK

Edward Jenner 2023-01-20

Double leucine zipper kinase (DLK, MAP3K12) and leucine zipper Carrying kinase (LZK, MAP3K13) are two homologous mitogen-activated protein kinases. They are regulators of neuronal apoptosis and axon degradation. And also…

Alzheimer Antibodydrug Neurological Disease

Semorinemab (RG 6100) is an Anti-Tau Humanized IgG4 Monoclonal Antibody

Edward Jenner 2023-01-09

Tau (Tubulin-associated unit) is a microtubule-associated protein (MAP) that is primarily present in axons. Besides, Tau is a multi-functional protein. Particularly, It takes part in the cross-linking and regulation of…

Alzheimer Inflammation Neurological Disease

SZM679 is an Orally Active and Selective RIPK1 Inhibitor, Can be Used to Research Alzheimer\’s Disease

Edward Jenner 2022-12-16

RIPK1 (Receptor-interacting serine/threonine-protein kinase 1), a 76-kDa protein, is an essential mediator of cell death and inflammation. This protein has a N-terminal kinase domain, a C-terminal death domain, and an…

Alzheimer

Elenbecestat (E2609) is an Orally Active and CNS-penetrant BACE-1 Inhibitor

Edward Jenner 2022-05-26

AAlzheimer's disease (AD)  is a neurodegenerative disease, characterized by progressive memory loss. In AD patients' brain, the Aβ-containing plaques and tau-containing neurofibrillary tangles exhibit significant accumulation. Aβ is primarily generated…

Neurological Disease

Tideglusib is an Irreversible GSK-3 Inhibitor

Edward Jenner 2021-11-23

Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase. Specifically, the enzyme is a key regulator of many signaling pathways. It includes cellular responses to Wnt, receptor tyrosine kinase,…

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  • Cabergoline is a D2-like Receptor Agonist for High Prolactin Levels Related Diseases

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You Missed

Hepatitis Hepatitis C Virus

Grazoprevir is a Hepatitis C virus NS3/4A Protease Inhibitor for Infection Research

Breast cancer Infection

Efbemalenograstim alfa is a Recombinant Fusion Protein for Neutropenia Research

Cancer Chronic Urticaria Inflammatory Uncategorized

Remibrutinib is an Orally Active BTK Inhibitor for Chronic Urticaria Research

Infection

Taurolidine is a Broad-spectrum Antimicrobial for Central Venous Catheter-Related Infections Research

Immune System Research

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