PfCLK3 is a protein kinase essential for maintaining the asexual blood stage of both P. falciparum and P. berghei. In mammalian cells, the CLK protein kinase family and the closely related SRPK family…
As previously introduced, we all have known that RRx-001, a hypoxia-selective epigenetic agent and a radio- and chem-sensitizer. Additionally, it triggers apoptosis and overcomes drug resistance in myeloma. RRx-001 exhibits…
Malaria has been a military problem throughout history capable of causing epidemics that stop military operations. Particularly, malaria has had a greater impact on world history than any other infectious…
In our previous blogs, we have introduced two compounds that have antimalarial activity, BDA-410 and UCT943. BDA-410 is a calpain inhibitor and UCT943 is an inhibitor of Plasmodium PI4K. Today,…
Malaria is one of the most important parasitic infections of humans and is responsible for over a million deaths each year. Scientists have extensively investigated the malaria parasite cysteine proteases…