Malaria is a parasitic disease caused by Plasmodium species, which are spread by mosquitoes. Erythrocytes are the replicating factories for malaria parasites. There are three malarial life-cycle stages: exoerythrocytic forms, asexual…
Glycogen synthase kinase-3 (GSK-3) is a serine-threonine kinase ubiquitously expressed and involved in the regulation of many cell functions. GSK-3 phosphorylates the microtubule-associated protein tau in mammalian cells. This hyperphosphorylation…
Malaria is one of the most widespread and ancient infectious diseases of humanity. In particular, Dihydroorotate dehydrogenase (DHODH) acts as a target for the development of new antimalarials. In addition,…
Malaria remains one of the most severe and life-threatening infectious diseases. Among the various Plasmodium spp., Plasmodium falciparum is the most virulent and life-threatening form, prevailing in Southeast Asia and Africa.…
Malaria is a mosquito-borne infectious disease that affects humans and other animals. Specifically, malaria caused Symptoms usually including fever, fatigue, vomiting and headache. Besides, malaria is due to the single-celled…
Cleavage and polyadenylation specificity factor (CPSF) is relevant to the cleavage of the 3' signaling region from a newly synthesized pre-messenger RNA (pre-mRNA) molecule. Specifically, it is in the process…
PfCLK3 is a protein kinase essential for maintaining the asexual blood stage of both P. falciparum and P. berghei. In mammalian cells, the CLK protein kinase family and the closely related SRPK family…
As previously introduced, we all have known that RRx-001, a hypoxia-selective epigenetic agent and a radio- and chem-sensitizer. Additionally, it triggers apoptosis and overcomes drug resistance in myeloma. RRx-001 exhibits…
Malaria has been a military problem throughout history capable of causing epidemics that stop military operations. Particularly, malaria has had a greater impact on world history than any other infectious…
In our previous blogs, we have introduced two compounds that have antimalarial activity, BDA-410 and UCT943. BDA-410 is a calpain inhibitor and UCT943 is an inhibitor of Plasmodium PI4K. Today,…