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AB928 is an Orally Active, Selective Dual A2aR and A2bR Antagonist

Edward Jenner 2021-10-12

Adenosine is generated through the hydrolysis of extracellular adenosine mono phosphate (AMP) by the ectonucleotidase CD73. It is an important mechanism for immunosuppression in cancer development. A2aR and A2bR drive…

Cancer Immunology

M2N12 is a Highly Selective Cdc25C Inhibitor

Edward Jenner 2021-03-16

Cell division cycle 25 (Cdc25) protein phosphatases play important roles in the cell cycle under normal conditions and in response to DNA damage. They could activate cyclin-dependent kinases (CDKs) through…

Cancer Immunotherapy

Poziotinib is an Orally Active and Irreversible pan-HER Inhibitor

Edward Jenner 2021-01-15

The HER protein is a transmembrane tyrosine kinase receptor and a member of the epidermal growth factor receptors (EGFRs) family. HER2 acts as an oncogene in carcinomas. In particular, HER2…

Cancer Immunology

EG01377 is a Selective Neuropilin-1 (NRP1) Inhibitor

Edward Jenner 2020-09-22

Neuropilin-1 (NRP1) is a membrane-bound co-receptor of the tyrosine kinase receptor, which can be used for vascular endothelial growth factor and signal protein family members. Specifically, NRP1 plays a variety…

Cancer Immunology HIV Viral Immunology

TC14012 is a Selective CXCR4 Inverse Agonist and CXCR7 Agonist

Edward Jenner 2020-08-19

CXC chemokine receptors are the complete membrane proteins and they can specifically bind and respond to CXC chemokine family cytokines. Specifically, they represent a subfamily of chemokine receptors, a large…

Cancer Immunology

BML-111 is a Lipoxin A4 Receptor Agonist

Edward Jenner 2020-07-11

Tumor angiogenesis plays an essential role in carcinogenesis, cancer progression, and metastasis. The inflammation is a key feature of the environment within and around tumors. Some studies indicate that the…

Bacterial Cancer Immunology

BPH-1358 is a Dual FPPS and UPPS Inhibitor

Edward Jenner 2019-11-11

As we all know, Farnesyl diphosphate synthase(FPPS) is an important drug target for bone resorption, cancer, and some infectious diseases. Besides, FPPS and undecaprenyl diphosphate synthase (UPPS) involves in bacterial…

Airway Inflammation

BAY 61-3606 is an Orally Active and Highly Selective SYK Inhibitor for Inflammatory Diseases

Edward Jenner 2019-09-03

Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase. Syk plays an important role in allergic diseases and inflammation. Thus, Syk is an attractive target for therapeutic kinase inhibitors. This…

Homeostasis Immune Checkpoint

BMS-1, a Novel Inhibitor of PD-1/PD-L1 Interaction

Edward Jenner 2019-04-06

Programmed death protein 1 (PD-1) is a major immunological checkpoint that belongs to the CD28 family. Importantly, it has an essential role in balancing protective immunity and immunopathology, homeostasis and…

Immune Checkpoint Innate Immune

RGX-104 Restricts Innate Immune Suppression in Cancer via Activating LXR/ApoE

Edward Jenner 2019-04-04

In cancer treatment, checkpoint inhibition of adaptive immunity is an important breakthrough of epoch-making significance. However, this therapy doesn’t work to many patients. Interestingly, researchers found that these non-responders usually…

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  • PRX-08066 is an orally active 5-HT2BR Antagonist with Vasodilation Effect for PAH
  • Apocynin is a NADPH oxidase (NOX) Inhibitor for Metabolic and Inflammation Research
  • Xylometazoline is an α-adrenergic Receptor Agonist for Nose Stuffiness Research
  • Elafibranor is a PPARα/δ Agonist for Metabolic Disease Research
  • Doravirine is a HIV-1 Inhibitor for Infection Research

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You Missed

Pulmonary Arterial Hypertension (PAH)

PRX-08066 is an orally active 5-HT2BR Antagonist with Vasodilation Effect for PAH

Cancer Immune Metabolic Disease

Apocynin is a NADPH oxidase (NOX) Inhibitor for Metabolic and Inflammation Research

Uncategorized

Xylometazoline is an α-adrenergic Receptor Agonist for Nose Stuffiness Research

NASH obesity

Elafibranor is a PPARα/δ Agonist for Metabolic Disease Research

Immune System Research

Up to date immunology information

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