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Tag: BRD4

GSK620 is a Potent and Orally Active pan-BET-BD2 Inhibitor

2021-01-08 Edward Jenner

The therapeutic potential of extra terminal domain inhibitor (iBET) has increasing studies both in oncology and immunoinflammatory. Moreover, iBETs are…

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Posted in: Arthritis, Hepatitis, Inflammation, Psoriasis Filed under: Anti-Inflammatory, BET BD2, BRD4, Psoriasis

ZL0580, a Selective BD1 BRD4 Inhibitor, Induces HIV Epigenetic Suppression

2020-03-12 Edward Jenner

HIV integrates its provirus into the host genome and establishes latent infection. Antiretroviral therapy (ART) can effectively suppress active HIV…

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Posted in: AIDs, HIV, Viral Immunology Filed under: BRD4, HIV, TAt

MS417 is a BET-Specific BRD4 Inhibitor

2020-01-17 Edward Jenner

NF-κB-mediated inflammation is a major pathology in kidney diseases, such as non-kidney inflammatory diseases, and rheumatoid arthritis. HIV infection in…

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Posted in: HIV, Inflammation, Rheumatoid Arthritis, Viral Immunology Filed under: BRD4, HIV, HIVAN, NF-κB

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