Autophagy is a multi-step pathway initiated through the ULK preinitiation complex, which consists of unc-51-like autophagy activating kinase 1 (ULK1)…
Neratinib is an irreversible tyrosine kinase inhibitor with IC50s of 59 nM and 92 nM for HER2 and EGFR, respectively.…
Amino acids are essential for protein synthesis, they are supporting cell growth, and metabolism. System L belongs to the family…
Mitosis is an attractive target for selective anticancer treatment. Mitotic kinases, including CDKs, AURKs, and PLK1, associate with tumor progression and prognosis.…
In previous blogs, we have introduced a lot of PROTAC based degraders, including TD-428, HJB97, A1874, etc. Coincidentally most of…