![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/01/SBP-7455-is-an-Orally-Active-Dual-ULK1-ULK2-Autophagy-Inhibitor-2020-01-23.jpg)
Autophagy is a multi-step pathway initiated through the ULK preinitiation complex, which consists of unc-51-like autophagy activating kinase 1 (ULK1)…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/01/Neratinib-is-an-Orally-Available-Irreversible-Tyrosine-Kinase-Inhibitor-2020-01-19.jpg)
Neratinib is an irreversible tyrosine kinase inhibitor with IC50s of 59 nM and 92 nM for HER2 and EGFR, respectively.…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/01/KMH-233-is-a-Reversible-and-Selective-LAT1-Inhibitor-2020-01-18.jpg)
Amino acids are essential for protein synthesis, they are supporting cell growth, and metabolism. System L belongs to the family…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/11/MKI-1-an-MASTL-Inhibitor-Exerts-Antitumor-and-Radiosensitizer-Activities-2020-12-01.jpg)
Mitosis is an attractive target for selective anticancer treatment. Mitotic kinases, including CDKs, AURKs, and PLK1, associate with tumor progression and prognosis.…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/11/BETd-246-is-a-PROTAC-Based-BET-BRD-Degrader-2020-11-12.jpg)
In previous blogs, we have introduced a lot of PROTAC based degraders, including TD-428, HJB97, A1874, etc. Coincidentally most of…