BI-425809 is a Selective and Orally Active GlyT1 Inhibitor
Glycine transporters (GlyTs) are plasmalemmal neurotransmitter transporters. GlyTs, which regulate brain glycine levels, is an inhibitory neurotransmitter with co-agonist activity for NMDA receptors (NMDARs). Meanwhile, GlyTs comprise glycine transporter type 1 (SLC6A9;…