IκB kinase 2 (IKK-2) plays a pivotal role in the nuclear factor-κB-regulated production of proinflammatory molecules by stimuli, such as tumor necrosis factor (TNF)-αand interleukin (IL)-1. Thus, inhibition of IKK-2…
Neuroinflammation is an inflammatory response within the brain or spinal cord. The production of cytokines, chemokines, reactive oxygen species, and secondary messengers mediate this inflammation Neuroinflammation occurs as a consequence…
Pulmonary fibrosis is a progressive and lethal lung disease. This disease is characterized by fibroblasts proliferation and the deposition of extracellular matrix (ECM) materials. Mechanically, it usually leads to collagen…