Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. In addition,…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/01/TAS6417-is-a-pan-Mutation-Selective-EGFR-Inhibitor-2020-01-20.jpg)
Despite dramatic response to first and second-generation EGFR TKIs, resistance emerges over time. The EGFR-T790M mutation accounts for more than…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/01/Neratinib-is-an-Orally-Available-Irreversible-Tyrosine-Kinase-Inhibitor-2020-01-19.jpg)
Neratinib is an irreversible tyrosine kinase inhibitor with IC50s of 59 nM and 92 nM for HER2 and EGFR, respectively.…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/01/AG-1478-is-a-Selective-EGFR-Tyrosine-Kinase-Inhibitor-2020-01-16.jpg)
Epidermal growth factor receptor (EGFR) is a transmembrane protein and a member of the ErbB receptor family. Specifically, EGFR is…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/01/Poziotinib-is-an-Orally-Active-and-Irreversible-pan-HER-Inhibitor-2020-01-15.jpg)
The HER protein is a transmembrane tyrosine kinase receptor and a member of the epidermal growth factor receptors (EGFRs) family.…