Despite dramatic response to first and second-generation EGFR TKIs, resistance emerges over time. The EGFR-T790M mutation accounts for more than…
Neratinib is an irreversible tyrosine kinase inhibitor with IC50s of 59 nM and 92 nM for HER2 and EGFR, respectively.…
Epidermal growth factor receptor (EGFR) is a transmembrane protein and a member of the ErbB receptor family. Specifically, EGFR is…
The HER protein is a transmembrane tyrosine kinase receptor and a member of the epidermal growth factor receptors (EGFRs) family.…
Epidermal growth factor receptor (EGFR) is a transmembrane receptor tyrosine kinase protein. EGFR plays an important role in controlling cell…