Gram-negative Archives - Immune System Research

SPR741, an Anti-biotic Potentiator, Inhibits Multidrug-Resistant Gram-negative Bacteria

2019-12-16 Edward Jenner

SPR741, an antibiotic adjuvant that can permeabilize the Gram-negative membrane. In this article, we will briefly introduce this compound in vitro and in vivo. SPR741 lacks significant antibacterial activity as…

ACHN-975 is a First-in-class and Selective LpxC Inhibitor

2019-10-21 Edward Jenner

The bacterial enzyme UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase (LpxC) catalyzes the first committed step of lipid A biosynthesis. Additionally, the process represents a promising target in the development of novel antibiotics against Gram-negative…

Immune System Research

Up to date immunology information.

Browsed by
Tag: Gram-negative

SPR741, an Anti-biotic Potentiator, Inhibits Multidrug-Resistant Gram-negative Bacteria

2019-12-16 Edward Jenner

ACHN-975 is a First-in-class and Selective LpxC Inhibitor

2019-10-21 Edward Jenner