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Tag: HER

Neratinib is an Orally Available, Irreversible Tyrosine Kinase Inhibitor

2021-01-19 Edward Jenner

Neratinib is an irreversible tyrosine kinase inhibitor with IC50s of 59 nM and 92 nM for HER2 and EGFR, respectively.…

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Posted in: Cancer Immunotherapy Filed under: Breast Cancer, EGFR, HER

Poziotinib is an Orally Active and Irreversible pan-HER Inhibitor

2021-01-15 Edward Jenner

The HER protein is a transmembrane tyrosine kinase receptor and a member of the epidermal growth factor receptors (EGFRs) family.…

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Posted in: Cancer Immunotherapy Filed under: Antitumor, Apoptosis, EGFR, HER, SNU216
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5-HT Anti-Inflammatory Anti-Tumor Antibacterial Antimalarial Antitumor Antiviral Apoptosis Autophagy Breast Cancer Chemokines COPD COVID-19 Cytokine Dopamine EGFR ER Stress HBV HCV HDAC HIV IFN IL-6 IL-17 Infection Inflammasome Integrin Interleukin IPF JAK Leukemia Low Toxicity Multidrug Resistance NF-κB p38 MAPK PI3K PPI Proteasome RIPK ROS T Cell Th17 TLR TNF TNF-α
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