Tyrosine kinase 2 (TYK2) is a member of the JAK kinase family. Besides, it regulates signal transduction downstream of the IL-23/IL-12 pathway and the type I interferon family receptor, pairing…
Stimulator of interferon genes (STING), an integral ER-membrane protein, is a protein that in humans is encoded by the STING1 gene. STING plays an important role in innate immunity. It…
In the previous blog, I have introduced C-176 as a strong and covalent mouse STING inhibitor. Today, I’d like to introduce another STINF inhibitor C-178 in the same article. STING,…
Chemokines are low-molecular weight proteins that mediate the migration of leucocytes. Crucially, chemokines exert their effects by binding to specific GPCRs expressed on the leucocyte surface. Of these, the chemokine…
IKK {IκB kinase} family plays a indispensable role in innate immunity by inducing NF-κB- and IRF -dependent gene transcription programmes required for the production of pro-inflammatory cytokines and IFNs. A…
TAK1 is also called Mitogen-activated protein kinase kinase kinase 7 (MAP3K7). It belongs to the serine/threonine protein kinase family. The kinase regulates cell death, and its activation is through a…
The abnormal activation of innate immune pathways partispate in the progress of various diseases. Unfortunately, the development of drugs specifically targeted molecules with interest and potential still remains challenging. A…