Ro 61-8048 is an Orally Active and Selective Kynurenine 3-Hydroxylase Inhibitor
Kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) is the expression product of the KMO (gene). It participates in tryptophan metabolism through the kynurenine catabolic pathway. Kynurenine 3-hydroxylase catalyzes the insertion of molecular oxygen…