Hsp90 is a molecular chaperone, it is essential for the conformational stability and activity of many key oncogenic proteins. These proteins include not only kinases such as ErbB2, B-Raf, Alk,…
Gamma secretase (γ-Secretase) is a kind of multi-subunit protease complex, which is an indispensable membrane protein. Specifically, γ-Secretase cleaves one-way transmembrane proteins at residues in the transmembrane domain. Besides, the…
The protein-protein interaction between menin and MLL fusion proteins plays a critical role in the pathogenesis of MLL leukemia. The genetic disruption of this interaction abrogates the development of acute…
Integrins are transmembrane receptors that facilitate cell-extracellular matrix (ECM) adhesion. The presence of integrins allows rapid and flexible responses to events at the cell surface. Specifically, inflammation results from a…
The vitamin D receptor (VDR) is a member of the nuclear receptor family of transcription factors. 1α,25(OH)2D3 is to mediate biological responses as a consequence of its interaction with both a…