Hsp90 is a molecular chaperone, it is essential for the conformational stability and activity of many key oncogenic proteins. These…
Gamma secretase (γ-Secretase) is a kind of multi-subunit protease complex, which is an indispensable membrane protein. Specifically, γ-Secretase cleaves one-way…
The protein-protein interaction between menin and MLL fusion proteins plays a critical role in the pathogenesis of MLL leukemia. The…
Integrins are transmembrane receptors that facilitate cell-extracellular matrix (ECM) adhesion. The presence of integrins allows rapid and flexible responses to…
The vitamin D receptor (VDR) is a member of the nuclear receptor family of transcription factors. 1α,25(OH)2D3 is to mediate biological…