The protein-protein interaction between menin and MLL fusion proteins plays a critical role in the pathogenesis of MLL leukemia. The genetic disruption of this interaction abrogates the development of acute…
Integrins are transmembrane receptors that facilitate cell-extracellular matrix (ECM) adhesion. The presence of integrins allows rapid and flexible responses to events at the cell surface. Specifically, inflammation results from a…
The vitamin D receptor (VDR) is a member of the nuclear receptor family of transcription factors. 1α,25(OH)2D3 is to mediate biological responses as a consequence of its interaction with both a…
Menin is a protein encoded by the MEN1 gene. MLL fusion proteins interact directly with menin to regulate the expression of MEIS1 and HOX genes, which drive leukemogenesis in MLL…