Lysyl oxidase-like 2 (LOXL2) is a secreted enzyme that catalyzes the formation of cross-linking in extracellular matrix proteins (collagen and elastin). There are five members of the human LOX protein…
Fibrosis is a formation of excess fibrous connective tissue in body, similar to scarring. They are involved in stimulated fibroblasts depositing connective tissue. Fibrosis occurs in various tissues of the…
The leading feature of the progressive disease fibrosis is the excessive deposition of extracellular matrix and crosslinked proteins. In particular, the two proteins, collagen and elastin, lead to tissue stiffening…