PXS-4787 is a Specific Pan-LOX (Lysyl Oxidase) Inhibitor
LOX (lysyl oxidase) is encoded in the human body by the LOX gene. This gene is located on human chromosome 5 and encodes a polypeptide of 417 amino acids. The…
PXS-5120A is an Irreversible LOXL2/3 Inhibitor with Anti-Fibrotic Activity
Lysyl oxidase-like 2 (LOXL2) is a secreted enzyme that catalyzes the formation of cross-linking in extracellular matrix proteins (collagen and elastin). There are five members of the human LOX protein…
PXS-5153A is A Lysyl Oxidase Like 2/3 Enzymatic Inhibitor
The leading feature of the progressive disease fibrosis is the excessive deposition of extracellular matrix and crosslinked proteins. In particular, the two proteins, collagen and elastin, lead to tissue stiffening…