AQX-435 is a Potent SHIP1 Activator and an Apoptosis Inducer
PI3Ks are key drivers of the survival and growth of normal B cells. PI3K catalyzes the phosphorylation of PI(4,5)P2 to generate PI(3,4,5)P3. It serves as a docking site at the…
TAS05567 is a Highly Selective, ATP-competitive and Orally Active Syk Inhibitor
Autoimmune diseases, including rheumatoid arthritis (RA) and immune thrombocytopenia (ITP), are caused by aberrant immune responses. ITP is an autoimmune bleeding disorder in which opsonization by platelet-specific autoantibodies results in…