Poly (ADP ribose) polymerase (PARP) is a family of proteins involved in many cellular processes, such as DNA repair, genomic stability, and programmed cell death. Specifically, PARP consists of four…
Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant myeloid cell infiltrates. The immunosuppression, fibrosis, T cell dysfunction, and poor prognosis in patients with PDAC associate with these infiltrates. The cells…
The sphingomyelin synthase 2 (SMS2) is a potential target for pharmacological intervention in atherosclerosis. However, as far as now, reports about selective SMS2 inhibitors and their pharmacological activities were lacked.…