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Immune System Research
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Tag: Melanoma

SB269970 is a 5-HT7 Receptor Antagonist

2022-01-15 Edward Jenner

5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the…

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Posted in: Fungal, Infection Filed under: COLO829, ERK1, ERK2, FLT3, Leukemia, MEK1, MEK2, Melanoma, PDGFRα, PDGFRβ, VEGFR1, VEGFR2

Hypothemycin, a Fungal Polyketide, is a Multikinase Inhibitor

2022-01-13 Edward Jenner

The kinase is an enzyme. And it catalyzes the transfer of a phosphate group from a high-energy donor molecule to…

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Posted in: Fungal, Infection Filed under: COLO829, ERK1, ERK2, FLT3, Leukemia, MEK1, MEK2, Melanoma, PDGFRα, PDGFRβ, VEGFR1, VEGFR2

L748337 is a Potent β3-Adrenergic Receptor Antagonist

2021-07-27 Edward Jenner

Adrenergic receptors (also known as adrenoceptors, ARs) belong to the guanine nucleotide-binding G protein-coupled receptor (GPCR) superfamily. And Adrenergic receptors…

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Posted in: Cancer Immunology Filed under: Adrenergic, B16F10, Melanoma

RRD-251 is an Inhibitor of Rb-Raf-1 Interaction

2020-12-16 Edward Jenner

Retinoblastoma protein (Rb), a tumor suppressor protein, is dysfunctional in several major cancers. Specifically, one of the functions of Rb…

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Posted in: Cancer Immunology Filed under: Melanoma, Raf

3M-011, a Cytokine Inducer, is a Dual TLR7/8 Agonist

2020-05-09 Edward Jenner

3M-011 is a potent dual toll-like receptor TLR7/8 agonist and a cytokine inducer. Firstly, in B16-F10 melanoma cells, 3M-011 treatment can decrease…

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Posted in: Influenza Virus, Viral Immunology Filed under: Cytokine, Melanoma, TLR
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