Rottlerin is a Specific PKC Inhibitor
Protein kinase C (PKC) is a family of protein kinase enzymes with 15 isoforms that can regulate the protein function. PKCs can control the function of otherproteins through the phosphorylation…
BC1618, an Orally Active Fbxo48 Inhibitor, Stimulates Ampk-Dependent Signaling
The adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a central regulator of metabolic pathways. Increasing AMPK activity is an attractive therapeutic target. Fbxo48 is an orphan ubiquitin E3 ligase subunit…
NV-5138 is the First Selective and Orally Active Brain mTORC1 Activator
Major depressive disorder (MDD) is a chronic illness. And it affects ~17% of the population and one leading cause of disability in the world. Currently, drugs that influence monoamine neurotransmission…