The current treatment of bacterial infections is challenged by a dramatic increase of multidrug-resistant (MDR) strains. In addition to Gram-negative MDR pathogens cause infection, Gram-positive pathogens, such as Staphylococcus aureus,…
SPR741, an antibiotic adjuvant that can permeabilize the Gram-negative membrane. In this article, we will briefly introduce this compound in vitro and in vivo. SPR741 lacks significant antibacterial activity as…
PfCLK3 is a protein kinase essential for maintaining the asexual blood stage of both P. falciparum and P. berghei. In mammalian cells, the CLK protein kinase family and the closely related SRPK family…
Tuberculosis (TB) is an important infectious disease threat worldwide. HIV coinfection/immunosuppression and widespread drug resistance contributes to the challenge of controlling TB. TB resulted from Mycobacterium tuberculosis. It is a…
Multidrug resistance (MDR) provokes obstruction in disease control by intensifying the possibility of spreading of resistant pathogens. It declines efficacy of treatment and, hence, resulting in prolonged time of infection…