![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/09/DPTIP-is-a-Brain-Penetrant-N-SMase-2-and-Exosome-Inhibitor-2020-09-12.jpg)
Neutral sphingomyelinase 2 (nSMase2) catalyzes the formation and release of extracellular vesicles (EVs) . Human nSMase2 catalyzes the hydrolysis of…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/05/GW4869-Noncompetitive-Neutral-Sphingomyelinase-Inhibitor-2019-05-18.jpg)
GW4869 was identified as a noncompetitive inhibitor of the enzyme neutral, magnesium-dependent sphingomyelinase (SMase) more than a decade ago. A…