N-SMase - Immune System Research

DPTIP is a Brain Penetrant N-SMase 2 and Exosome Inhibitor

Neutral sphingomyelinase 2 (nSMase2) catalyzes the formation and release of extracellular vesicles (EVs) . Human nSMase2 catalyzes the hydrolysis of sphingomyelin to phosphorylcholine and ceramide. DPTIP, a potent brain penetrant…

Inflammation

GW4869, a Noncompetitive Neutral Sphingomyelinase (N-SMase) Inhibitor

Edward Jenner 2019-05-19

GW4869 was identified as a noncompetitive inhibitor of the enzyme neutral, magnesium-dependent sphingomyelinase (SMase) more than a decade ago. A study from Chiara Luberto identified and verified the function of…

DPTIP is a Brain Penetrant N-SMase 2 and Exosome Inhibitor

GW4869, a Noncompetitive Neutral Sphingomyelinase (N-SMase) Inhibitor

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