N-SMase Archives - Immune System Research

DPTIP is a Brain Penetrant N-SMase 2 and Exosome Inhibitor

2020-09-12 Edward Jenner

Neutral sphinghomyelinase 2 (nSMase2) catalyzes the formation and release of extracellular vesicles (EVs) . Human nSMase2 catalyzes the hydrolysis of sphingomyelin to phosphorylcholine and ceramide. DPTIP, a potent brain penetrant…

GW4869, a Noncompetitive Neutral Sphingomyelinase (N-SMase) Inhibitor

2019-05-19 Edward Jenner

GW4869 was identified as a noncompetitive inhibitor of the enzyme neutral, magnesium-dependent sphingomyelinase (SMase) more than a decade ago. A study from Chiara Luberto identified and verified the function of…

Immune System Research

Up to date immunology information.

Browsed by
Tag: N-SMase

DPTIP is a Brain Penetrant N-SMase 2 and Exosome Inhibitor

2020-09-12 Edward Jenner

GW4869, a Noncompetitive Neutral Sphingomyelinase (N-SMase) Inhibitor

2019-05-19 Edward Jenner