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Tag: NAM

HTL14242 is an Orally Active mGlu5 NAM

2021-03-23 Edward Jenner

Metabotropic glutamate receptor 5 (mGlu5) is an excitatory GQ coupled G protein-coupled receptor, which is mainly expressed in the postsynaptic…

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Posted in: Neurological Disease Filed under: mGlu5, NAM

TAK-615 is a LPA1 Receptor Negative Allosteric Modulator (NAM)

2020-12-03 Edward Jenner

Lysophosphatidic acid (LPA) is a phospholipid growth factor that stimulates proliferation, chemotaxis, cation currents, and K+ currents in retinal pigment…

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Posted in: Fibrosis, Pulmonary Fibrosis Filed under: Drugdiscovery, LPA1, NAM
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5-HT Anti-Inflammatory Anti-Tumor Antibacterial Antimalarial Antitumor Antiviral Apoptosis Autophagy Breast Cancer Chemokines COPD COVID-19 Cytokine EGFR HBV HCV HDAC HIV IFN IL-6 IL-17 Infection Integrin Interferon Interleukin IPF JAK Leukemia Low Toxicity Multidrug Resistance Necroptosis NF-κB p38 MAPK PPI Proteasome RIPK STAT STING T Cell Th17 TLR TNF TNF-α α4β1
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