NAM - Immune System Research

HTL14242 is an Orally Active mGlu5 NAM

Metabotropic glutamate receptor 5 (mGlu5) is an excitatory GQ coupled G protein-coupled receptor, which is mainly expressed in the postsynaptic region of neurons. Besides, they regulate cellular signal transduction and…

Fibrosis Pulmonary Fibrosis

TAK-615 is a LPA1 Receptor Negative Allosteric Modulator (NAM)

Edward Jenner 2020-12-03

Lysophosphatidic acid (LPA) is a phospholipid growth factor that stimulates proliferation, chemotaxis, cation currents, and K+ currents in retinal pigment epithelial (RPE) cells. In particular, LPA is an extracellular signaling…

HTL14242 is an Orally Active mGlu5 NAM

TAK-615 is a LPA1 Receptor Negative Allosteric Modulator (NAM)

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