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Tag: Neuroblastoma

PB28 is a Selective σ2 Receptor Agonist with High Affinity

2020-06-30 Edward Jenner

Sigma Ligands has cytotoxic activity in vitro and is able to induce ceramide/caspase-independent apoptosis. In addition, these ligands down-regulate P-glycoprotein…

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Posted in: Cancer Immunology, SARS-CoV Filed under: Apoptosis, Caspase, COVID-19, Neuroblastoma, σ2

Lorlatinib is an Orally Active and Dual ALK/ROS1 Inhibitor

2019-12-18 Edward Jenner

Oncogenic c-Ros oncogene1 (ROS1) fusion kinases have been identified in a variety of human cancers and are attractive targets for…

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Posted in: Cancer Immunology Filed under: ALK, Carcinoma, Neuroblastoma, NSCLC, ROS

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