NOD2 - Immune System Research

GSK717 is a Selective NOD2 (Nucleotide-Binding Oligomerization Domain 2) Inhibitor

NOD2 (nucleotide-binding oligomerization domain 2) is an intracellular pattern recognition receptor. NOD2 is one of cytoplasmic PRRs, and antigen-presenting cells and certain mucosal epithelia primarily express it. It assembles with…

Inflammation

GSK583 is an Orally Active and Selective RIP2 Kinase Inhibitor

Edward Jenner 2019-09-02

In previous blogs, I have introduces several RIPK inhibitors, including RIP1 inhibitors RIPA-56, PK68, GSK547, GNE684, and GSK2982772. But the RIP2 inhibitors are lacked, today, I’d like to make up…

GSK717 is a Selective NOD2 (Nucleotide-Binding Oligomerization Domain 2) Inhibitor

GSK583 is an Orally Active and Selective RIP2 Kinase Inhibitor

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