Glioblastoma (GBM) is the most common and most aggressive primary malignant brain tumour in adults, with a high morbidity, high mortality and poor patient prognosis. Platinum-based drugs, including cisplatin, are…
AUNP-12 is a peptide antagonist of the PD-1 signaling pathway, which acts as an immunosuppressant for cancer therapy. In this article, we will introduce the properties of NP-12 in vitro and in vivo.…
The blockade of the PD-1/PD-L1 immune checkpoint pathway with monoclonal antibodies has provided significant advances in cancer therapy. However, the antibody-based immunotherapies carry a number of disadvantages, including the high…
Glioblastomas (also called GBM) are malignant Grade IV tumors, where a large portion of tumor cells are reproducing and dividing at any given time. They are nourished by an ample and…
Programmed death protein 1 (PD-1) is a major immunological checkpoint that belongs to the CD28 family. Importantly, it has an essential role in balancing protective immunity and immunopathology, homeostasis and…