Glioblastoma (GBM) is the most common and most aggressive primary malignant brain tumour in adults, with a high morbidity, high…
PI3Kδ belongs to the class I Phosphoinositide 3-kinases (PI3Ks). PI3Kδ plays a critical role in chronic obstructive pulmonary disease (COPD).…
SLE is a complex autoimmune inflammatory disease that affects multiple organs with unpredictable flares. Autoantibody/antigen immune-complexes in turn can activate…
PI3Ks are key drivers of the survival and growth of normal B cells. PI3K catalyzes the phosphorylation of PI(4,5)P2 to…
Phosphoinositide 3-kinase (PI3K) plays an indispensable role in the signal transduction of numerous cellular functions via the formation of the…