SLE is a complex autoimmune inflammatory disease that affects multiple organs with unpredictable flares. Autoantibody/antigen immune-complexes in turn can activate TLR7 and/or TLR9 in plasmacytoid dendritic cells (pDCs) leading to…
PI3Ks are key drivers of the survival and growth of normal B cells. PI3K catalyzes the phosphorylation of PI(4,5)P2 to generate PI(3,4,5)P3. It serves as a docking site at the…
Phosphoinositide 3-kinase (PI3K) plays an indispensable role in the signal transduction of numerous cellular functions via the formation of the second messenger PIP3. In previous blogs, I have introduced a…
The phosphatidylinositol-3-kinase (PI3K) signal transduction pathway plays an indispensable role in different cellular processes involving metabolism, proliferation, differentiation or activation. Therefore, targeting PI3K pathway represents an interesting approach in diseases…