Prostaglandin - Immune System Research

CAY10471 is a Selective and Orally Active CRTH2 Antagonist

Edward Jenner 2020-05-07

CAY10471 (TM30089) is a potent, selective, and orally active prostaglandin D2 receptor CRTH2 antagonist. In PC12 cells, CAY10471 blocks 15d-PGJ2-induced p38 MAP kinase activation and decreases phosphorylation of p-38 MAP…

Inflammation

DuP-697 is a Selective and Orally Active COX-2 Inhibitor

Edward Jenner 2020-03-26

COX-2 is the more important source of prostanoid formation in inflammation and in proliferative diseases. In particular, COX-2 prefers prostaglandin I synthase and the microsomal PGES isozymes. DuP-697 is an…

CAY10471 is a Selective and Orally Active CRTH2 Antagonist

DuP-697 is a Selective and Orally Active COX-2 Inhibitor

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