IKK (IκB kinase) is an enzyme complex that is the core element of the NF-κB cascade. The complex has two…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/10/GKT136901-is-a-Selective-and-Orally-Active-Inhibitor-of-NADPH-Oxidase-NOX14-2020-10-24.jpg)
NADPH oxidases (NOX), catalyzing the reduction of molecular oxygen to form the superoxide radical anion (O₂⁻) and hydrogen peroxide (H₂O₂).…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2020/07/RP101075-is-a-Potent-and-Orally-Active-S1PR-Agonist-2020-07-25.jpg)
Sphingosine-1-phosphate (S1P) is a ligand for G-protein-coupled receptors, it is responsible for some cell-intrinsic and extrinsic activities. RPC1063 is a…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/09/IOX4-is-a-Highly-Selective-PHD2-Inhibitor-2019-09-17.jpg)
Prolyl hydroxylases (PHDs) target hypoxia-inducible factor-1α (HIF-1α) for degradation. Hypoxia inactivates PHDs, causing accumulation of HIF-1α. In turn, HIF-1 further…