![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/12/PF-06651600-is-a-Orally-Active-and-Covalent-JAK3-Selective-Inhibitor-2019-12-2.jpg)
JAK/STAT-dependent cytokines are essential for the development, proliferation, and function of T-cells. The JAK family of nonreceptor tyrosine kinases is…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/08/SR0987-is-a-RORγt-Agonist-to-EnhanceP-rotectiveI-mmunity-2019-08-31.jpg)
The transcriptional activity of most nuclear receptors (NRs) can be modulated by small lipophilic molecules such as hormones, vitamins, steroids,…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/08/SR2211-is-a-Selective-RORγ-Inverse-Agonist-2019-08-29.jpg)
Retinoic acid receptor-related orphan receptors (RORs) are ligand-dependent transcriptional factors and members of the nuclear receptor superfamily. In fact, RORs…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/08/A-9758-is-a-Selective-RORγt-Inverse-Agonist-2019-08-29.jpg)
The retinoic acid-related orphan receptor (ROR) isoforms RORα (NR1F1), RORβ (NR1F2), and RORγ (NR1F3) are members of the steroid nuclear…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2019/07/PRN694-is-a-Dual-Inhibitor-of-ITK-and-RLK-2019-07-30.jpg)
Interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK or TXK) are essential mediators of intracellular signaling in both normal…