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Antigen-Induced Arthritis Arthritis Immunotherapy

PF-06651600 is a Orally Active and Covalent JAK3-Selective Inhibitor

Edward Jenner 2019-12-02

JAK/STAT-dependent cytokines are essential for the development, proliferation, and function of T-cells. The JAK family of nonreceptor tyrosine kinases is composed of four isoforms: JAK1, JAK2, JAK3, and TYK2. Functioning…

Immunology

SR0987 is a RORγt Agonist to Enhance Protective Immunity

Edward Jenner 2019-08-31

The transcriptional activity of most nuclear receptors (NRs) can be modulated by small lipophilic molecules such as hormones, vitamins, steroids, and synthetic molecules. The NR1F subfamily of NRs contains the…

Autoimmune Disorders Multiple Sclerosis Rheumatoid Arthritis

SR2211 is a Selective RORγ Inverse Agonist

Edward Jenner 2019-08-29

Retinoic acid receptor-related orphan receptors (RORs) are ligand-dependent transcriptional factors and members of the nuclear receptor superfamily. In fact, RORs regulate inflammation, metabolic disorders, and circadian rhythm. RORs include RORα…

Inflammation Psoriasis Rheumatoid Arthritis

A-9758 is a Selective RORγt Inverse Agonist

Edward Jenner 2019-08-28

The retinoic acid-related orphan receptor (ROR) isoforms RORα (NR1F1), RORβ (NR1F2), and RORγ (NR1F3) are members of the steroid nuclear hormone receptor superfamily. RORs play prominent roles in a variety…

Colitis

PRN694 is a Dual Inhibitor of ITK and RLK

Edward Jenner 2019-07-30

Interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK or TXK) are essential mediators of intracellular signaling in both normal and neoplastic T-cells and natural killer (NK) cells. Thus, ITK…

Cancer Immunology

GSK547, a Mono-Selective RIPK1 Inhibitor, drives Macrophage-Mediated Th1/Th17 and CTL Activation

Edward Jenner 2019-07-26

RIPK1 (receptor-interacting serine/threonine protein kinase 1) belongs to the receptor interacting protein kinases family, which contains seven members. RIPK1 plays a vital role in cell survival and cell death. It…

Arthritis Rheumatoid Arthritis

CH-223191 Inhibits Smoking-Induced Aggravation of Experimental Arthritis via Aryl Hydrocarbon Receptor

Edward Jenner 2019-06-30

CH-223191 inhibits smoking-induced aggravation of experimental arthritis via aryl hydrocarbon receptor (AHR). Firstly, as we all know, smoking has become a major risk factor of people’s health. It involves in…

Auto-Inflammatory Inflammation

DB550, Targeting PLCγ1, Prevents Th17-driven Inflammation via Disrupting the CD95-PLCγ1 Interaction

Edward Jenner 2019-06-25

CD95L is a transmembrane ligand (m-CD95L) releases a soluble ligand (s-CD95L) that is cleaved by metalloproteases. Unlike m-CD95L, the interaction between s-CD95L and CD95 fails to recruit caspase-8 and FADD…

Autoimmune Disorders Skin Inflammation

S18-000003 is an Orally Acitive RORγt Inhibitor

Edward Jenner 2019-06-22

RORγ (RAR-related orphan receptor gamma) is a protein of the nuclear receptor family of transcription factors. RORγ (RORγ1) and RORγt (RORγ2) are two isoforms, encoded by the same RORC gene.…

Colitis Inflammation

MS402, a BD1-Selective BET BRD Inhibitor, Blocks Th17 Cells Differentiation

Edward Jenner 2019-06-19

T-helper 17 (Th17) cells is a unique CD4+ T-cell subset characterized by production of interleukin-17 (IL-17). Especially, IL-17 is a highly inflammatory cytokine with robust effects on stromal cells in…

Recent Posts

  • PRX-08066 is an orally active 5-HT2BR Antagonist with Vasodilation Effect for PAH
  • Apocynin is a NADPH oxidase (NOX) Inhibitor for Metabolic and Inflammation Research
  • Xylometazoline is an α-adrenergic Receptor Agonist for Nose Stuffiness Research
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You Missed

Pulmonary Arterial Hypertension (PAH)

PRX-08066 is an orally active 5-HT2BR Antagonist with Vasodilation Effect for PAH

Cancer Immune Metabolic Disease

Apocynin is a NADPH oxidase (NOX) Inhibitor for Metabolic and Inflammation Research

Uncategorized

Xylometazoline is an α-adrenergic Receptor Agonist for Nose Stuffiness Research

NASH obesity

Elafibranor is a PPARα/δ Agonist for Metabolic Disease Research

Immune System Research

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