GSK-872 is a RIP3 Inhibitor
Necroptosis is a programmed form of necrosis, or inflammatory cell death. Especially, necroptosis is an alternative mode of regulated cell death mimicking features of apoptosis and necrosis. Necroptosis is triggered…
Necroptosis is a programmed form of necrosis, or inflammatory cell death. Especially, necroptosis is an alternative mode of regulated cell death mimicking features of apoptosis and necrosis. Necroptosis is triggered…
Galectins are β-galactoside-binding proteins. They participate in intracellular trafficking, cell adhesion, and cell–cell signaling. They play a pivotal role in physiological and pathological activities, such as, inflammation, immune response, and…
NLRP3 (NACHT, LRR and PYD domains-containing protein 3) is a component of inflammasome, expressed mainly in macrophages. It reports products of injured cells like extracellular ATP and crystalline uric acid.…
The prevalence of asthma and the associated cost burden for the health care system is high. The chemokine receptor Chemokine (C-C motif) receptor 8 (CCR8) is associated with asthma. A…
Arenaviruses are a significant cause of hemorrhagic fever, an often-fatal disease. Arenaviruses are single-stranded ribonucleic acid (RNA) viruses that cause chronic infections in rodents and zoonotically acquired disease in humans…
NF-κBs are homo- or heterodimers of the structurally related subunits p65 (RelA), RelB, cRel, p50 and p52. NF-κB plays a key role in regulating the immune response to infection. NFκBs…
The hepatitis B virus is a DNA virus. It belongs to a Hepadnaviridae family of viruses. The virus primarily exists in the liver, but is also present in the blood…
Necroptosis is a programmed necrosis or inflammatory cell death. It is different from apoptosis. Necroptosis is due to cellular damage or infiltration by pathogens. It is a component of inflammatory…
Necroptosis is an alternative form of programmed cell death that is triggered when apoptosis is inhibited. Apoptosis is characterized by a requirement for caspases. Receptor-interacting protein kinase 3 (RIP3 or RIPK3)…
EGFR (Epidermal Growth Factor Receptor) is a receptor on the surface of cells which is expressed in many normal epithelial tissues, including skin. The EGFR signaling pathway plays an important…