AS1810722 is an Orally Active STAT6 Inhibitor
Signal transducers and activators of transcription 6 (STAT6) is an important transcription factor in IL-4 signaling pathway. STAT6 is also a key regulator of the Th2 cell immune response. Therefore,…
Signal transducers and activators of transcription 6 (STAT6) is an important transcription factor in IL-4 signaling pathway. STAT6 is also a key regulator of the Th2 cell immune response. Therefore,…
Inhibition of monocyte and macrophage function by targeting chemokine receptors represents an attractive strategy for therapeutic intervention in inflammatory diseases. Blockade of CCR2 on whole blood monocytes was demonstrated ex…
JMV 449 is a pseudopeptide analogue of neurotensin-(8-13). It is about 3 times more potent than neurotensin in binding to mouse brain membranes and in contracting the guinea-pig ileum. Nurotensin…
Glucokinase (GK) is the rate-limiting enzyme of hepatic glucose metabolism and acts as a sensor for glucose-stimulated insulin release in β-cells. Glucokinase catalyses the conversion of glucose to glucose-6 phosphate. It…
More and more evidence suggesting that the adenosine A2A receptor is a promising target for antiparkinson treatment. Adenosine A2A receptors always locate within the caudate-putamen, nucleus accumbens, and olfactory tubercle.…
The transcriptional enhanced associate domain (TEAD) is a transcription factor. In mammals, TEAD has four different isoforms namely TEAD1 (TEF-1/NTEF), TEAD2 (TEF-4/ETF), TEAD3 (TEF-5/ETFR-1), and TEAD4 (TEF-3/ETFR-2/FR-19). And there is…
Cholesterol 24-hydroxylase (CH24H), also commonly known as CYP46A1, is a brain-specific enzyme. This enzyme is a member of the cytochrome P450 (CYP) superfamily of enzymes. Cholesterol 24-hydroxylase is a monooxygenase…
During the drug discovery development, most new chemical entities (NCEs) suffer from limiting oral absorption after an oral administration. Besides the first-pass metabolism, some other factors such as aqueous solubility,…