TAK-779 is an Antagonist of CCR5 and CXCR3, with Anti-HIV-1 Effect
Nowadays, people are no strangers to AIDS. It is a kind of infectious disease caused by HIV. The latter primarily acts on human immune system, like CD4+ T cells. These…
Nowadays, people are no strangers to AIDS. It is a kind of infectious disease caused by HIV. The latter primarily acts on human immune system, like CD4+ T cells. These…
In our previous blogs, we have mentioned autoimmune disease many times. There are various types of autoimmune diseases, such as rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and psoriasis. The…
Multiple sclerosis is a demyelinating disease with damaged insulating covers of nerve cells in the brain and spinal cord. It is a kind of inflammatory disease, affects the central nervous…
Renal ischemia/reperfusion injury (IR) is a major clinical problem found in shock, renal transplantation and other clinical settings. Neutrophils and macrophages rapidly infiltrate the kidney after renal ischemia-reperfusion injury. Chemokines…
RORγ (RAR-related orphan receptor gamma) is a protein of the nuclear receptor family of transcription factors. RORγ (RORγ1) and RORγt (RORγ2) are two isoforms, encoded by the same RORC gene.…
NLRP3 (NACHT, LRR and PYD domains-containing protein 3) is a component of inflammasome, expressed mainly in macrophages. It reports products of injured cells like extracellular ATP and crystalline uric acid.…
Familial cold autoinflammatory syndrome is a condition that causes episodes of fever, skin rash, and joint pain after exposure to cold temperatures. In people with familial cold autoinflammatory syndrome, the…
A study from Henry W. B. Johnson discovered and described KZR-504 as a highly selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2). Immunoproteasome is always expressed in nonhematopoietic…
Autoimmune diseases are condition arising from an abnormal immune response to a normal body part. Autoimmune diseases are generally characterized by a dysregulation of cytokine signaling. Cytokine signaling is an…
Autoimmune diseases are due to an abnormal immune response to a normal body part. They have many types, such as rejection of organ transplantation, allergy. The nuclear hormone receptor RORC2…