JAK/STAT-dependent cytokines are essential for the development, proliferation, and function of T-cells. The JAK family of nonreceptor tyrosine kinases is composed of four isoforms: JAK1, JAK2, JAK3, and TYK2. Functioning…
Bone morphogenetic proteins (BMPs) are important regulators of embryonic development and stem cell fate decisions. In human ESCs, BMP4 promotes cell differentiation, so that maintenance of human ESC self-renewal requires…
AS2863619 is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. Firstly, in vitro, AS2863619 is a potent Foxp3 inducer in Tconv cells. AS2863619…
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease and associated morbidity and mortality worldwide. HCV associates with an increased incidence of liver fibrosis, cirrhosis, and…
MYC proteins include MYC (also known as c-MYC), MYCL, and MYCN. They play critical roles in tumorigenesis and therapeutic resistance. MYC proteins are implicated in up to 70% of all human…