![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/04/K-975-is-an-Orally-Active-and-Selective-TEAD-Inhibitor-2021-05-04.jpg)
The transcriptional enhanced associate domain (TEAD) is a transcription factor. In mammals, TEAD has four different isoforms namely TEAD1 (TEF-1/NTEF),…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/04/Soticlestat-is-an-Orally-Active-and-First-in-Class-Cholesterol-24-Hydroxylase-Inhibitor-2021-05-04.jpg)
Cholesterol 24-hydroxylase (CH24H), also commonly known as CYP46A1, is a brain-specific enzyme. This enzyme is a member of the cytochrome…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/04/CP-100356-is-an-Orally-Active-Dual-MDR1-BCRP-Inhibitor-2021-05-01-1.jpg)
During the drug discovery development, most new chemical entities (NCEs) suffer from limiting oral absorption after an oral administration. Besides…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/04/CHF5407-is-a-Muscarinic-M3-Receptor-Antagonist-2021-04-29.jpg)
Muscarinic M3 receptors are a subtype of Muscarinic acetylcholine receptors (mAChRs). Specifically, mAChRs is acetylcholine receptor, which forms a G-protein-coupled…
![](https://www.Immune-System-Research.com/"wp-content/uploads"/2021/04/PNRI-299-is-a-Selective-AP-1-Transcription-Inhibitor-2021-04-27.jpg){kind=spacer}
Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli. Specifically,…