LSD1 is an important histone demethylase. LSD1 overpresses in many malignancies, including some leukemia, breast, small-cell lung, colorectal, prostate, neuroblastoma, and bladder cancers. Moreover, LSD1 is also an important component…
BI-1230 is a potent and digit nanomolar inhibitor of HCV NS3 protease and of viral replication. BI-1230 is also highly selective against other serine/cysteine proteases. It also shows good Pharmacokinetic(PK)…
The current treatment of bacterial infections is challenged by a dramatic increase of multidrug-resistant (MDR) strains. In addition to Gram-negative MDR pathogens cause infection, Gram-positive pathogens, such as Staphylococcus aureus,…
The G-protein activated, inward-rectifying potassium (K+) channels, “GIRKs”, are a family of ion channels (Kir3.1-Kir3.4). Besides, GIRKs are comprised of various homo- and heterotetrameric combinations of four different subunits. In addition, These…
Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant myeloid cell infiltrates. The immunosuppression, fibrosis, T cell dysfunction, and poor prognosis in patients with PDAC associate with these infiltrates. The cells…