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Immune System Research

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Infection SARS-CoV-2

Setomimycin is a Potent Antibiotic for the Research of COVID‑19

Edward Jenner 2023-07-04

COVID‑19 (Coronavirus disease 2019) is a contagious disease caused by the virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Importantly, COVID-19 transmits when infectious particles are breathed in or come…

antibiotic Bacterial Fungal HIV Infection

Siamycin I, an HIV Fusion Inhibitor, Interacts with Lipid II and Inhibits Cell Wall Biosynthesis

Edward Jenner 2023-02-24

HIV is a virus that affects the immune system. HIV infects important cells in the human immune system, such as helper T cells (especially CD4+T cells), macrophages, and dendritic cells.…

Bacterial Infection Inflammation Lung Inflammation

Lefamulin (BC-3781) is an Orally Active Antibiotic, Inhibiting Bacterial Protein Synthesis

Edward Jenner 2022-10-31

Bacteria are small single-celled organisms. Bacteria exist almost everywhere on Earth and are vital to the planet's ecosystems. Some species can live under extreme conditions of temperature and pressure. The…

Lung Inflammation Pulmonary Fibrosis

Dovramilast is a PDE4 inhibitor for the Research of TB

Edward Jenner 2022-08-16

Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond. Usually, people speaking of PDE are referring to cyclic nucleotide phosphodiesterase. while, the superfamily of PDE enzymes is classified into…

Inflammation Neurological Disease Parkinson’s

Lactacystin, an Antibiotic, is a Selective 20S Proteasome Inhibitor

Edward Jenner 2022-05-23

The proteasome is part of the main mechanism by which cells regulate specific protein concentration and degrade misfolded proteins. Specifically, ubiquitin is a key molecule known to cooperate with proteasome.…

Inflammation

Ikarugamycin, an Antibiotic is an Inhibitor of Clathrin-Mediated Endocytosis (CME)

Edward Jenner 2022-03-15

Ikarugamycin is an antibiotic and a inhibitor of clathrin-mediated endocytosis (CME). Cell surface receptors and their ligands can be internalized by some mechanistically distinct endocytic pathways. Those signal pathways include…

Bacterial

Avibactam is a Covalent and Reversible non-β-Lactamase Inhibitor

Edward Jenner 2021-11-20

Some Gram-negative pathogens have accumulated enough resistance mechanisms to render them virtually untreatable by modern antibacterial chemotherapy. A mainstay for the treatment of Gram-negative infections is the β-lactam classes of…

Bacterial Cancer Immunology

Plicamycin is a Selective Specificity Protein 1 (Sp1) Inhibitor

Edward Jenner 2021-10-03

Cancer initiation and progression are mediated through dysregulation of multiple signaling pathways. Specificity protein 1 (Sp1) is a zinc-finger transcription factor that regulates multiple cellular functions and promotes tumor progression…

Bacterial Cancer Immunotherapy HSV Viral Immunology

Brefeldin A (BFA) is a Lactone Antibiotic and a Specific Protein Trafficking Inhibitor

Edward Jenner 2021-09-22

Antibiotics, also known as antibacterials, are medications that destroy or slow down the growth of bacteria. Since ancient times, many civilizations used topical application of mouldy bread, with many references…

Bacterial Cancer Immunotherapy

Ionomycin (SQ23377) is a Selective Calcium Ionophore and an Antibiotic

Edward Jenner 2021-09-14

In the furnaces of the stars the elements evolved from hydrogen. When oxygen and neon captured successive α particles, the element calcium was born. Calcium ions (Ca2+) are some of…

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You Missed

Pulmonary Arterial Hypertension (PAH)

PRX-08066 is an orally active 5-HT2BR Antagonist with Vasodilation Effect for PAH

Cancer Immune Metabolic Disease

Apocynin is a NADPH oxidase (NOX) Inhibitor for Metabolic and Inflammation Research

Uncategorized

Xylometazoline is an α-adrenergic Receptor Agonist for Nose Stuffiness Research

NASH obesity

Elafibranor is a PPARα/δ Agonist for Metabolic Disease Research

Immune System Research

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