PF-184 is a Potent and Selective IKK2 Inhibitor
IKK (IκB kinase) is an enzyme complex that is the core element of the NF-κB cascade. The complex has two kinases (IKKα and IKKβ) and a regulatory subunit, NEMO/IKKγ. IKKα…
CAY10590 (GK115) is a Potent and Selective sPLA2 Inhibitor
PLA2 (phospholipases A2) are enzymes that can hydrolyze the fatty acyl ester bond at the sn-2 position of glycerophospholipid. After hydrolysis, free fatty acids are then formed, including arachidonic acid, and…
T16A(inh)-C01 is an Inhibitor of TMEM16A (ANO1)
Calcium-activated chloride channels (CaCCs) are always expressed in epithelial and nonepithelial cells. They are involved in epithelial fluid secretion, sensory signal transduction, smooth muscle contraction, oocyte fertilization, and other functions.…
Vilanterol, a β2-AR Agonist, Has Potential to Treat Asthma and COPD
Vilanterol (GW642444) is a potent, orally active and long-acting β2-AR (β2-adrenergic receptor) agonist with inherent 24-hour activity. The pEC50s for β2-AR, β1-AR and β3-AR are 10.37, 6.98 and 7.36, respectively.…
MRS 1754 is a Selective Antagonist Radioligand for A2B Adenosine Receptor
Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. To date, there are four types of adenosine receptors in humans: A1,…