Mammalian cell division involves an orderly progression through four distinct phases: G1 (growth phase 1), S (DNA synthesis), G2 (growth…
AS2863619 is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. Firstly, in vitro,…